We previously reported that mice chronically irradiated with low-dose-rate γ rays had significantly shorter mean life spans than nonirradiated controls. This life shortening appeared to be due ...

Comparative genomic hybridization (CGH) is a technique that has greatly facilitated detection of gains and losses in DNA copy number, and has been of particular utility in elucidating the pattern of ...

Although numerous platforms have been developed to support array CGH studies, they all revolve around a common principle of detecting copy number alterations between two samples (Figure 1). These ...

In addition to the surprising revelation that our chromosomes harbor fewer genes than originally predicted, the Human Genome Project also unveiled that all individuals share approximately 99.9% of ...

Early efforts to examine genomic changes in the clinical setting relied on cytogenetic techniques such as chromosome karyotyping, a widely used approach to examine chromosomes and identify changes ...