Accurate transmission of the genetic information requires complete duplication of the chromosomal DNA each cell division cycle. However, the idea that replication forks would form at origins of DNA ...

Replication forks encounter problems due to causes such as chemical damage to the DNA template, from both endogenous and exogenous agents, and problems with the protein–DNA complexes that are ...

Focusing on the schematic illustration in a, two DNA polymerase molecules are active at the fork at any one time. One moves continuously to produce the new daughter DNA molecule on the leading strand, ...